In order to implement the "Belt and Road" initiative, since 2016, under the guidance of the National Health Commission, the Chinese Hospital Association, collaborating with each of the bilateral and multilateral partners, has prompted the establishments of China-CEEC Hospital Cooperation Alliance, China-Israel Hospital Cooperation Alliance, SCO Hospital Cooperation Alliance, China-ASEAN Hospital Cooperation Alliance (HCA). The HCA of China-France, China-Africa, China-Arab and China-SAARC have been proposed. China-US healthcare exchange and cooperation is also prompted under the mechanism of "China-US Track II Dialog on Healthcare".

Department of International Cooperation of CHA was established in 2017, with a working scope covering the relevant international Hospital Cooperation Alliances (HCA), host of relevant academic conferences and exchange activities, CHA-HMT hospital management international training program, etc.